The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Sep. 18, 2020
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Brian A. Sherer, Nashua, NH (US);
Xiaoling Chen, Chestnut Hill, MA (US);
Esther Cleary, Somerville, MA (US);
Nadia Brugger, Cambridge, MA (US);
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4523 (2006.01); C07D 401/14 (2006.01); C07D 215/18 (2006.01); C07D 413/04 (2006.01); C07D 401/12 (2006.01); A61K 31/4709 (2006.01); A61P 35/00 (2006.01); C07D 215/12 (2006.01); C07D 215/14 (2006.01); C07D 241/42 (2006.01); C07D 401/04 (2006.01); C07D 413/14 (2006.01); C07D 451/02 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/4709 (2013.01); A61P 35/00 (2018.01); C07D 215/12 (2013.01); C07D 215/14 (2013.01); C07D 215/18 (2013.01); C07D 241/42 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 451/02 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01);
Abstract
A method of administering to a patient in need thereof or contacting with a biological sample, a compound related to Formula I-e or pharmaceutically acceptable compositions thereof, is useful to inhibit activity of TLR7/8 or a mutant thereof and/or to treat a TLR7/8-mediated disorder.