The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Jun. 08, 2018
NH Theraguix, Villeurbanne, FR;
Universite Claude Bernard Lyon 1, Villeurbanne, FR;
Centre National DE LA Recherche Scientifique—cnrs, Paris, FR;
François Lux, Lyons, FR;
Olivier Tillement, Fontaines Saint-Martin, FR;
Fabien Rossetti, Villeurbanne, FR;
Vivek Thakare, Nasik, IN;
Vu Long Tran, Ho Chi Minh, VN;
NH THERAGUIX, Villeurbanne, FR;
Universite Claude Bernard Lyon 1, Villeurbanne, FR;
Centre National de La Recherche Gantifote—CNRS—, Paris, FR;
Abstract
The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0<C≤8. The invention also relates to the obtained ultrasmall silica nanoparticles.