The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Apr. 27, 2016
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Charles P. Venditti, Potomac, MD (US);
Jennifer L. Sloan, Silver Spring, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); A61K 39/002 (2006.01); A61K 48/00 (2006.01); C07K 14/435 (2006.01); A61P 43/00 (2006.01); A61K 47/26 (2006.01); C12N 15/67 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 47/26 (2013.01); A61P 43/00 (2018.01); C07K 14/435 (2013.01); C12N 15/67 (2013.01); C12N 15/85 (2013.01); C12N 2750/14143 (2013.01);
Abstract
The present invention provides a synthetic MMACHC polynucleotide comprising a polynucleotide encoding MMACHC that is codon-optimized for expression in a human. Also provided is a polypeptide encoded by a synthetic MMACHC polynucleotide, an expression vector comprising a MMACHC gene sequence under the control of a chicken beta actin (CBA) promoter, and an expression vector comprising a synthetic MMACHC polynucleotide. Methods of treating cobalamin C deficiency and for detecting or tracking exogenous MMACHC are also provided.