The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Feb. 17, 2017
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
Randi B. Silver, New York, NY (US);
Stefan Worgall, New York, NY (US);
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/472 (2006.01); A61P 11/00 (2006.01); A61K 31/197 (2006.01); A61K 31/47 (2006.01); A61K 31/4418 (2006.01); A61K 31/4709 (2006.01);
U.S. Cl.
CPC ...
A61K 31/472 (2013.01); A61K 31/197 (2013.01); A61K 31/4418 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61P 11/00 (2018.01);
Abstract
The disclosure provides a method comprising administering HIF stabilizing small molecule drugs to premature infants, whose survival is dependent upon mechanical ventilation and/or supplemental oxygen, to counteract the pathological effects of hyperoxia on lung development. Data in a mouse model of hyperoxia-induced neonatal lung disease supports a treatment with a HIF stabilizer during high oxygen exposure protects the lung. HIF stabilizers can be administered via various routes, including in an aerosolized state using a ventilator, intravenous, intraperitoneal or subcutaneous injection.