The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2022

Filed:

May. 30, 2018
Applicant:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Inventors:

Ann Begovich, El Cerrito, CA (US);

Cindy Cheung, Fremont, CA (US);

Javelin Chi, Pleasanton, CA (US);

Grantland Hillman, Oakland, CA (US);

Dwight Kuo, Castro Valley, CA (US);

Michael Lee, San Ramon, CA (US);

Chitra Manohar, San Ramon, CA (US);

Xiaoju Max Ma, San Carlos, CA (US);

Ellen Ordinario, Oakland, CA (US);

Jaya Rajamani, Pleasanton, CA (US);

Huan Truong, Milpitas, CA (US);

Assignee:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); C12Q 1/6851 (2018.01); C12Q 1/686 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/6851 (2013.01); C12Q 1/686 (2013.01); C12Q 2537/143 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/16 (2013.01); C12Q 2600/166 (2013.01);
Abstract

Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.


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