The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2022
Filed:
Dec. 13, 2019
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Anastasia Khvorova, Westborough, MA (US);
Neil Aronin, Newtonville, MA (US);
Marie Cecile Didiot, Worcester, MA (US);
Reka Haraszti, Tubingen, DE;
Assignee:
University of Massachusetts, Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/88 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/88 (2013.01); C12N 15/1137 (2013.01); A01K 2267/0337 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/311 (2013.01); C12N 2310/313 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3181 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/531 (2013.01);
Abstract
In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.