The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2022
Filed:
Jan. 11, 2019
Biomarin Pharmaceutical Inc., Novato, CA (US);
Augustus O. Okhamafe, Concord, CA (US);
Sean M. Bell, Novato, CA (US);
G. Nick Zecherle, Novato, CA (US);
Kris Antonsen, San Rafael, CA (US);
Yanhong Zhang, San Rafael, CA (US);
Kieu Ly Tran, San Francisco, CA (US);
Paul A. Fitzpatrick, Berkeley, CA (US);
Emil D. Kakkis, San Rafael, CA (US);
Michel Claude Vellard, San Rafael, CA (US);
Daniel J. Wendt, Walnut Creek, CA (US);
Mubarack Muthalif, Novato, CA (US);
BIOMARIN PHARMACEUTICAL INC., Novato, CA (US);
Abstract
Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.