The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2022

Filed:

Mar. 31, 2016
Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Christoph Clemens, Biberach an der Riss, DE;

Jochen Schaub, Schemmerhofen, DE;

Marie Link, Biberach an der Riss, DE;

Peter Schorn, Langenau, DE;

Torsten Schulz, Biberach an der Riss, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C07K 16/28 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0682 (2013.01); C07K 16/2887 (2013.01); C12N 5/0031 (2013.01); C07K 2317/24 (2013.01); C12N 2500/02 (2013.01); C12N 2500/24 (2013.01); C12N 2500/32 (2013.01); C12N 2500/46 (2013.01); C12N 2511/00 (2013.01);
Abstract

The present invention provides a basal cell culture medium and a feed medium with novel amino acid ratios and/or iron choline citrate as iron carrier that result in improved performance of mammalian cell culture processes, such as CHO cultivation and protein production processes, in particular in increased product titer (e.g. of monoclonal antibodies). Also provided are methods for culturing mammalian cells and producing a protein of interest using said basal cell culture medium and optionally feed medium. The invention also provides for a medium platform that comprises (i) the basal cell culture medium and (ii) the feed medium.


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