The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2022
Filed:
Nov. 22, 2017
Argenx Bv, Zwijnaarde, BE;
The Board of Regents of the University of Texas System, Austin, TX (US);
Peter Ulrichts, Destelbergeb, BE;
Christophe Blanchetot, Destellbergen, BE;
Torsten Dreier, Sint Martens Latem, BE;
Johannes de Haard, NA Oudelande, NL;
E. Sally Ward Ober, Dallas, TX (US);
Nicolas G. H. Ongenae, Ghent, BE;
argenx BV, Ghent, BE;
The Board of Regents of the University of Texas System, Austin, TX (US);
Abstract
Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.