The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2022
Filed:
Oct. 19, 2018
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Radoslaw P. Nowak, Boston, MA (US);
Eric S. Fischer, Newton, MA (US);
Nathanael S. Gray, Boston, MA (US);
Tinghu Zhang, Brookline, MA (US);
Zhixiang He, Brookline, MA (US);
Brian Groendyke, Chestnut Hill, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Abstract
Disclosed are heterobifunctional compounds that effectuate selective degradation of a target protein, and which include a targeting ligand that binds a target protein and at least one other protein, a ligand that binds an E3 ubiquitin ligase or a component of E3 ubiquitin ligase, and a specificity modulating linker that links the first ligand and the second ligand. Pharmaceutical compositions containing the compounds, and methods of using and making the compounds are also disclosed.