The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2022

Filed:

Aug. 05, 2019
Applicants:

Southern Research Institute, Birmingham, AL (US);

Uab Research Foundation, Birmingham, AL (US);

Inventors:

Mark J. Suto, Homewood, AL (US);

Vandana V. Gupta, Birmingham, AL (US);

Wei Zhang, Wilmington, MA (US);

Joanne Murphy-Ullrich, Birmingham, AL (US);

Assignees:

UAB RESEARCH FOUNDATION, Birmingham, AL (US);

SOUTHERN RESEARCH INSTITUTE, Birmingham, AL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/52 (2006.01); A61P 19/04 (2006.01); A61P 35/04 (2006.01); C07D 241/08 (2006.01);
U.S. Cl.
CPC ...
C07D 241/52 (2013.01); A61P 19/04 (2018.01); A61P 35/04 (2018.01); C07D 241/08 (2013.01);
Abstract

The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.


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