The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2022
Filed:
Mar. 02, 2018
Applicant:
Linda Chia-hui Yu, Taipei, TW;
Inventors:
Assignee:
NATIONAL TAIWAN UNIVERSITY, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 217/04 (2006.01); A61P 1/00 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
C07D 217/04 (2013.01); A61P 1/00 (2018.01); C07D 401/06 (2013.01);
Abstract
A series of 8-phenyl-isoquinoline derivatives (I) exhibit high binding affinity to 5-HTreceptor (5-HTR) and demonstrate potent antinociceptive activity in two animal models for Irritable Bowel Syndrome (IBS) by intraperitoneal injection (i.p.) or by oral administration (p.o.). These 5-HTreceptor antagonists are a new class of therapeutic agents for the treatment of IBS.