The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2022

Filed:

Aug. 22, 2016
Applicant:

National Cheng Kung University, Tainan, TW;

Inventors:

Yee-Shin Lin, Tainan, TW;

Yu-Hung Chen, Tainan, TW;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); A61K 39/385 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); A61K 39/385 (2013.01); C12N 7/00 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55583 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6087 (2013.01); A61K 2039/6093 (2013.01); B82Y 5/00 (2013.01); C12N 2770/24134 (2013.01);
Abstract

The present invention relates to a biodegradable nanocomplex. The biodegradable nanocomplex comprises a first electrically charged substance, a charge-redistribution substance, a second electrically charged substance and a carried substance, for holding the carried substance inside. The first electrically charged substance and the carried substance have the same electrical polarity, and the biodegradable nanocomplex has a nonuniformally and positively charge distribution along a radial direction thereof. The nonuniformally and positively charge distribution comprises a first electrically charged portion having substantially electrical neutrality, a second electrically charged portion surrounding the first electrically charged portion, and a third electrically charged portion surrounding the second electrically charged portion, in which the third electrically charged portion comprises an outermost surface of the biodegradable nanocomplex, thereby modulating the carried substance towards the desired immune responses via the nonuniformally and positively charge distribution.


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