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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11504337 B1

PDFFull Text
Date of Patent:
Nov. 22, 2022

Filed:

Jul. 18, 2019

Polynucleotides encoding methylmalonyl-coa mutase

Applicant:

Modernatx, Inc., Cambridge, MA (US);

Inventors:

Paolo Martini, Boston, MA (US);

Vladimir Presnyak, Manchester, NH (US);

Kerry Benenato, Sudbury, MA (US);

Stephen Hoge, Brookline, MA (US);

Iain McFadyen, Arlington, MA (US);

Ellalahewage Sathyajith Kumarasinghe, Harvard, MA (US);

Assignee:

ModernaTX, Inc., Cambridge, MA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Dana H Shin

Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 9/51 (2006.01); C12N 9/90 (2006.01); A61K 9/127 (2006.01); A61P 3/00 (2006.01); A61P 43/00 (2006.01); A61K 38/52 (2006.01); A61K 48/00 (2006.01); C12N 15/52 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5123 (2013.01); A61K 9/1272 (2013.01); A61K 38/52 (2013.01); A61K 48/005 (2013.01); A61P 3/00 (2018.01); A61P 43/00 (2018.01); C12N 9/90 (2013.01); C12N 15/52 (2013.01); C12Y 504/99002 (2013.01); A61K 38/00 (2013.01);
Abstract

The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.

Find Patent Forward Citations

Martini, Paolo. (2022). Polynucleotides encoding methylmalonyl-coa mutase (U.S. Patent No. 11504337). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11504337

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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