The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
Dec. 09, 2016
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Benjamin E. Deverman, Pasadena, CA (US);
Viviana Gradinaru, Flintridge, CA (US);
Ken Y. Chan, Pasadena, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/015 (2006.01); A61K 38/08 (2019.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C07K 7/06 (2006.01); A61K 38/00 (2006.01); A61K 38/02 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/20 (2006.01); A61K 38/43 (2006.01); A61K 38/47 (2006.01); A61K 38/48 (2006.01); A61K 38/50 (2006.01); A61K 48/00 (2006.01); C07K 16/18 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 38/08 (2013.01); C07K 7/06 (2013.01); C07K 14/005 (2013.01); C07K 14/015 (2013.01); C12N 7/00 (2013.01); A61K 38/00 (2013.01); A61K 38/02 (2013.01); A61K 38/1709 (2013.01); A61K 38/185 (2013.01); A61K 38/2093 (2013.01); A61K 38/43 (2013.01); A61K 38/47 (2013.01); A61K 38/4813 (2013.01); A61K 38/50 (2013.01); A61K 48/00 (2013.01); C07K 16/18 (2013.01); C07K 2319/00 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 2310/122 (2013.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01); C12N 2330/51 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01); C12Y 302/0102 (2013.01); C12Y 304/14009 (2013.01); C12Y 305/01015 (2013.01);
Abstract
Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases.