The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
Jul. 13, 2017
Applicant:
Bioarctic Ab, Stockholm, SE;
Inventors:
Lars Lannfelt, Stockholm, SE;
Dag Sehlin, Uppsala, SE;
Greta Hultqvist, Uppsala, SE;
Stina Syvänen, Uppsala, SE;
Assignee:
BioArctic AB, Stockholm, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/18 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61P 25/28 (2006.01); A61P 25/18 (2006.01); A61P 25/16 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2881 (2013.01); A61K 47/555 (2017.08); A61K 47/6801 (2017.08); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/28 (2018.01); C07K 16/18 (2013.01); G01N 33/6896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01);
Abstract
The present invention relates to a brain delivery protein, comprising a target binding antibody which binds to a target in a mammalian brain; two carrier moieties, each of which being capable of monovalent interaction with a protein expressed on a blood brain barrier (BBB) endothelial cell, wherein each of said carrier moieties is linked to a C-terminal end of the target binding antibody. The present invention moreover relates to use of such brain delivery proteins in therapy or diagnosis or for research of e.g. neurodegenerative disorders, and other brain diseases.