The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
Aug. 20, 2020
Applicants:
The General Hospital Corporation, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Assignees:
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/12 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); C07K 7/08 (2006.01); C07K 14/35 (2006.01); A61K 39/00 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1289 (2013.01); A61K 38/00 (2013.01); A61K 39/395 (2013.01); C07K 7/08 (2013.01); C07K 14/35 (2013.01); A61K 39/00 (2013.01); C07K 16/00 (2013.01); C07K 2317/41 (2013.01); C07K 2317/70 (2013.01); C07K 2317/732 (2013.01); Y02A 50/30 (2018.01);
Abstract
Described herein are methods of treating, diagnosing, and/or prognosing a disease in a subject relating to detection of the glycosylation state of the antibodies present in the subject. In some embodiments, the disease can be an infection. In some embodiments, an antibody glycosylation state that is indicative of the presence of a disease, or a need for treatment of a disease can be reduced glycosylation (e.g., galactosylation, sialation, fucosylation, and/or afucosylated branched glycoforms).