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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11498896 B1

PDFFull Text
Date of Patent:
Nov. 15, 2022

Filed:

Mar. 20, 2020

Dopamine d2 receptor ligands

Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Edward Holson, Newton Highlands, MA (US);

Florence Fevrier Wagner, Ashland, MA (US);

Michel Weiwer, Cambridge, MA (US);

Edward Scolnick, Wayland, MA (US);

Michelle Palmer, Harvard, MA (US);

Luka Dordevic, Trieste, IT;

Michael C. Lewis, Dedham, MA (US);

Jennifer Q. Pan, Acton, MA (US);

Yan-Ling Zhang, Lexington, MA (US);

Qihong Xu, Newton, MA (US);

Assignees:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Charanjit Aulakh

Int. Cl.
CPC ...
C07D 405/06 (2006.01); A61K 31/453 (2006.01); C07D 207/12 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 451/06 (2006.01); C07D 471/10 (2006.01); C07D 491/048 (2006.01); C07D 491/052 (2006.01); C07D 491/056 (2006.01); C07D 491/107 (2006.01); C07D 211/18 (2006.01); C07D 211/38 (2006.01); C07D 211/42 (2006.01); C07D 211/48 (2006.01); C07D 211/58 (2006.01); C07D 211/62 (2006.01); C07D 211/70 (2006.01); C07D 211/22 (2006.01); A61P 25/18 (2006.01); A61P 25/16 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07D 207/12 (2013.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); C07D 211/18 (2013.01); C07D 211/22 (2013.01); C07D 211/38 (2013.01); C07D 211/42 (2013.01); C07D 211/48 (2013.01); C07D 211/58 (2013.01); C07D 211/62 (2013.01); C07D 211/70 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 405/06 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 451/06 (2013.01); C07D 471/10 (2013.01); C07D 491/048 (2013.01); C07D 491/052 (2013.01); C07D 491/056 (2013.01); C07D 491/107 (2013.01); C07K 14/70571 (2013.01);
Abstract

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

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