The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
May. 09, 2018
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Yoshito Kishi, Cambridge, MA (US);
Kenzo Yahata, Osaka, JP;
Vemula Praveen Kumar, Somerville, MA (US);
Sudheer Babu Vaddela, Bellevue, WA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 45/45 (2006.01); C07C 67/343 (2006.01); C07D 307/20 (2006.01); C07F 7/18 (2006.01); C07C 69/738 (2006.01); C07D 319/06 (2006.01); C07D 309/10 (2006.01);
U.S. Cl.
CPC ...
C07C 45/455 (2013.01); C07C 67/343 (2013.01); C07C 69/738 (2013.01); C07D 307/20 (2013.01); C07D 309/10 (2013.01); C07D 319/06 (2013.01); C07F 7/1804 (2013.01);
Abstract
Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated ('Fe/Cu-mediated') coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.