The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
Nov. 02, 2016
Applicant:
Frank Ebetino ET Al., Pasadena, CA (US);
Inventors:
Frank Ebetino, Pasadena, CA (US);
Robert Boeckman, Honeoye Falls, NY (US);
Lianping Xing, Webster, NY (US);
Lifeng Xiao, Rochester, NY (US);
Brendan Boyce, Woodbury, NY (US);
Assignee:
BIOVINC, LLC, Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/00 (2006.01); A61K 47/54 (2017.01); C07F 9/6561 (2006.01); A61K 49/00 (2006.01); C07K 5/078 (2006.01); C07F 9/6558 (2006.01); C07K 5/062 (2006.01); A61P 19/00 (2006.01); A61P 35/00 (2006.01); A61K 31/69 (2006.01); C07K 5/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/548 (2017.08); A61K 31/69 (2013.01); A61K 49/0032 (2013.01); A61K 49/0052 (2013.01); A61P 19/00 (2018.01); A61P 35/00 (2018.01); C07F 9/6561 (2013.01); C07F 9/65583 (2013.01); C07F 9/65586 (2013.01); C07K 5/06043 (2013.01); C07K 5/06139 (2013.01); C07K 5/06191 (2013.01);
Abstract
The present invention provides compositions and methods for providing controllable local delivery of a conjugate of bortezomib (Btz) and a bisphosphonate to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.