The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
Mar. 27, 2020
Applicant:
University of Southern California, Los Angeles, CA (US);
Inventor:
Yong Zhang, Los Angeles, CA (US);
Assignee:
University of Southern California, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/07 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61K 47/64 (2017.01); A61K 47/60 (2017.01); A61P 35/00 (2006.01); A61K 31/537 (2006.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
A61K 38/07 (2013.01); A61K 31/537 (2013.01); A61K 31/704 (2013.01); A61K 47/548 (2017.08); A61K 47/549 (2017.08); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61K 47/6815 (2017.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01);
Abstract
Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NADanalogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.