The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2022
Filed:
Oct. 20, 2016
The Broad Institute, Inc., Cambridge, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Instituto Carlos Slim DE LA Salud, A.c., Mexico City, MX;
William C. Hahn, Newton, MA (US);
Andrew Aguirre, Boston, MA (US);
April Cook, Boston, MA (US);
Glenn Cowley, Cambridge, MA (US);
Robin Meyers, Cambridge, MA (US);
David E. Root, Brookline, MA (US);
Aviad Tsherniak, Cambridge, MA (US);
Barbara Weir, Brookline, MA (US);
Francisca Vazquez, Chestnut Hill, MA (US);
THE BROAD INSTITUTE INC., Cambridge, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
INSTITUTO CARLOS SLIM DE LA SALUD, A.C., Mexico City, MX;
Abstract
The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.