The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2022
Filed:
Oct. 05, 2016
Biontech SE, Mainz, DE;
Tron—translationale Onkologie an Der Universitätsmedizin Der Johannes Gutenberg-universität Mainz Ggmbh, Mainz, DE;
Alexandra Orlandini Von Niessen, Mainz, DE;
Stephanie Fesser, Mannheim, DE;
Britta Vallazza, Darmstadt, DE;
Tim Beissert, Gross-Gerau, DE;
Andreas Kuhn, Mainz, DE;
Ugur Sahin, Mainz, DE;
Marco Alexander Poleganov, Egelsbach, DE;
Abstract
The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.