The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 08, 2022

Filed:

Dec. 01, 2016
Applicants:

Katholieke Universiteit Leuven, Leuven, BE;

Institut D'investigacions Biomediques August Pi I Sunyer (Idibaps), Barcelona, ES;

Inventors:

Catherine Verfaillie, Leuven, BE;

Ruben Boon, Leuven, BE;

Pau Sancho Bru, Barcelona, ES;

Mar Col Loperena, Barcelona, ES;

Luis Perea Sanchez, Barcelona, ES;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0672 (2013.01); G01N 33/5014 (2013.01); C12N 2501/113 (2013.01); C12N 2501/119 (2013.01); C12N 2501/155 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01);
Abstract

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.


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