The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 08, 2022

Filed:

Apr. 20, 2018
Applicants:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Beth Israel Deaconess Medical Center, Boston, MA (US);

Inventors:

Gordon J. Freeman, Brookline, MA (US);

Vassiliki A. Boussiotis, Brookline, MA (US);

Xia Bu, Brookline, MA (US);

Vikram R. Juneja, Boston, MA (US);

Arlene H. Sharpe, Brookline, MA (US);

Nikolaos Patsoukis, Boston, MA (US);

Jessica Weaver, Brighton, MA (US);

Laura Strauss, Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C07K 16/28 (2006.01); C07K 16/44 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2818 (2013.01); C07K 16/44 (2013.01); G01N 33/5011 (2013.01); G01N 33/57492 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); G01N 2333/70596 (2013.01); G01N 2440/14 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01); G01N 2500/20 (2013.01); G01N 2800/52 (2013.01);
Abstract

The present invention is based, in part, on the discovery of monoclonal and polyclonal antibodies that specifically bind to phosphorylated PD-1, as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for diagnostic, prognostic, and therapeutic purposes.


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