The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2022
Filed:
Nov. 02, 2017
Vysoka Skola Chemicko-technologicka V Praze, Prague, CZ;
Vyzkumny Ustav Veterinarniho Lekarstvi, V. V. I., Brno, CZ;
Apigenex S.r.o., Prague, CZ;
Miroslav Ledvina, Prague, CZ;
Roman Effenberg, Celakovice, CZ;
Jaroslav Turanek, Brno, CZ;
Elissa Bartheldyova, Unin, CZ;
Ladislav Droz, Prague, CZ;
Josef Masek, Brno, CZ;
Frantisek Hubatka, Brno, CZ;
VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, Prague, CZ;
VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I., Brno, CZ;
APIGENEX S.R.O., Prague, CZ;
Abstract
New aminooxylipids of general formula I, wherein n=5-30 and X is polymethylene linker of the general formula II where n=2-10, or X is polyethylene glycol linker of the general formula III, wherein n=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH)C—O—(C═O)—HN—(CH)—NH, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH)C—O—(C═O)—HN—(CH)—[O—(CH)]—O—(CH)NH, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n=5-30, produces N-Boc-aminolipids of general formula VI, wherein n=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.