The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2022
Filed:
Dec. 17, 2018
The Medical College of Wisconsin, Inc., Milwaukee, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Joseph T. Barbieri, New Berlin, WI (US);
Eric A. Johnson, Milwaukee, WI (US);
Sabine Pellett, Milwaukee, WI (US);
William H. Tepp, Milwaukee, WI (US);
Amanda Przedpelski, Milwaukee, WI (US);
The Medical College of Wisconsin, Inc., Milwaukee, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.