The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2022
Filed:
Feb. 12, 2016
Applicant:
The Johns Hopkins University;
Inventors:
Fan Pan, Baltimore, MD (US);
Duojia Pan, Baltimore, MD (US);
Drew M. Pardoll, Brookeville, MD (US);
Joseph Barbi, East Amherst, NY (US);
Benjamin Park, Chicago, IL (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/409 (2006.01); A61K 31/351 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/409 (2013.01); A61K 31/351 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01);
Abstract
Yes-associated protein (Yap), a downstream co-activator of the Hippo pathway, is highly expressed in the Treg cell subset, and is critical to maintain its suppressive activity. Originally discovered in, the Hippo signaling pathway is a major regulator of cellular growth and proliferation in mammals. Loss of Yap expression in Treg cells can lead to superior anti-tumor immune responses, and thus, Yap is an important immunotherapeutic target for cancer.