The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 01, 2022

Filed:

May. 08, 2020
Applicants:

Stelic Institute & Co., Tokyo, JP;

(National University Corporation) Niigata University, Niigata, JP;

Inventors:

Hiroyuki Yoneyama, Tokyo, JP;

Kenji Suzuki, Niigata, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/10 (2006.01); A61K 31/396 (2006.01); A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 48/00 (2006.01); A61P 9/10 (2006.01); A61P 1/00 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/0053 (2013.01); A61K 9/08 (2013.01); A61K 9/10 (2013.01); A61K 31/396 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 48/0075 (2013.01); A61P 1/00 (2018.01); A61P 9/10 (2018.01); A61P 17/02 (2018.01); A61P 19/02 (2018.01);
Abstract

The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.


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