The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 01, 2022

Filed:

Nov. 09, 2017
Applicant:

Neumodx Molecular, Inc., Ann Arbor, MI (US);

Inventors:

Michael T. Kusner, Ann Arbor, MI (US);

Sundaresh Brahmasandra, Ann Arbor, MI (US);

Jeffrey Williams, Ann Arbor, MI (US);

Robert Jaekel, Ann Arbor, MI (US);

Assignee:

NeuMoDx Molecular, Inc., Ann Arbor, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01L 7/00 (2006.01); B01L 9/00 (2006.01); C12N 15/10 (2006.01); C12Q 1/6806 (2018.01); C12M 3/00 (2006.01); C12Q 1/68 (2018.01); C12M 1/12 (2006.01); B81C 3/00 (2006.01); C12M 3/06 (2006.01); B81C 1/00 (2006.01); B29C 65/48 (2006.01); B29C 65/00 (2006.01); B29L 31/00 (2006.01); B29C 65/60 (2006.01); B29C 65/08 (2006.01); C12Q 1/686 (2018.01); B29K 21/00 (2006.01); C12N 13/00 (2006.01); C12Q 1/6813 (2018.01);
U.S. Cl.
CPC ...
C12N 15/1013 (2013.01); B01L 3/502 (2013.01); B01L 3/508 (2013.01); B01L 3/5027 (2013.01); B01L 3/50273 (2013.01); B01L 3/502707 (2013.01); B01L 3/502738 (2013.01); B01L 3/527 (2013.01); B01L 3/567 (2013.01); B01L 7/525 (2013.01); B81C 1/00119 (2013.01); B81C 3/001 (2013.01); C12M 23/16 (2013.01); C12M 23/42 (2013.01); C12M 25/02 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6806 (2013.01); B01L 3/5025 (2013.01); B01L 3/502715 (2013.01); B01L 3/502723 (2013.01); B01L 3/502746 (2013.01); B01L 3/502761 (2013.01); B01L 3/523 (2013.01); B01L 7/52 (2013.01); B01L 2200/025 (2013.01); B01L 2200/0605 (2013.01); B01L 2200/0615 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/10 (2013.01); B01L 2200/12 (2013.01); B01L 2200/142 (2013.01); B01L 2300/021 (2013.01); B01L 2300/022 (2013.01); B01L 2300/044 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0672 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0809 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/0883 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/0893 (2013.01); B01L 2300/123 (2013.01); B01L 2300/14 (2013.01); B01L 2300/16 (2013.01); B01L 2300/1822 (2013.01); B01L 2300/1827 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0478 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/065 (2013.01); B01L 2400/0622 (2013.01); B01L 2400/0655 (2013.01); B01L 2400/0694 (2013.01); B01L 2400/086 (2013.01); B29C 65/08 (2013.01); B29C 65/484 (2013.01); B29C 65/606 (2013.01); B29C 66/1122 (2013.01); B29C 66/21 (2013.01); B29C 66/3022 (2013.01); B29C 66/542 (2013.01); B29C 66/71 (2013.01); B29C 66/81423 (2013.01); B29C 66/8322 (2013.01); B29K 2021/00 (2013.01); B29L 2031/756 (2013.01); B81B 2201/054 (2013.01); B81C 2203/032 (2013.01); C12N 13/00 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6813 (2013.01);
Abstract

A system, configured to facilitate processing and detection of nucleic acids, the system comprising a process fluid container and a cartridge comprising: a top layer, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a detection chamber, comprises a portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region.


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