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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11485737 B1

PDFFull Text
Date of Patent:
Nov. 01, 2022

Filed:

Jul. 27, 2020

Diaryl substituted 5,5-fused ring compounds as c5ar inhibitors

Applicant:

Chemocentryx, Inc., Mountain View, CA (US);

Inventors:

Pingchen Fan, Fremont, CA (US);

Christopher W. Lange, El Cerrito, CA (US);

Rebecca M. Lui, Mountain View, CA (US);

Viengkham Malathong, Belmont, CA (US);

Venkat Reddy Mali, Cupertino, CA (US);

Sreenivas Punna, Sunnyvale, CA (US);

Rajinder Singh, Belmont, CA (US);

Yibin Zeng, Foster City, CA (US);

Penglie Zhang, Foster City, CA (US);

Assignee:

CHEMOCENTRYX, INC., San Carlos, CA (US);

Attorney:

Mintz Levin Cohn Ferris Glovsky and Popeo PC

Primary Examiner:

Theodore R Howelu

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 9/00 (2006.01); A61K 31/4162 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 19/02 (2006.01); A61P 11/00 (2006.01); A61P 25/28 (2006.01); A61P 37/06 (2006.01); A61P 7/00 (2006.01); A61K 9/10 (2006.01); A61K 9/08 (2006.01); A61P 37/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/0078 (2013.01); A61K 9/08 (2013.01); A61K 9/10 (2013.01); A61K 31/4162 (2013.01); A61K 45/06 (2013.01); A61P 7/00 (2018.01); A61P 11/00 (2018.01); A61P 19/02 (2018.01); A61P 25/28 (2018.01); A61P 35/00 (2018.01); A61P 37/06 (2018.01); A61P 37/00 (2018.01);
Abstract

The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

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