The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2022
Filed:
Dec. 19, 2019
Applicant:
Ksq Therapeutics, Inc., Lexington, MA (US);
Inventors:
Jehrod Burnett Brenneman, Marblehead, MA (US);
Elsa Beyer Krall, Cambridge, MA (US);
Michael Schlabach, Belmont, MA (US);
Andrew Alistair Wylie, Newton, MA (US);
Assignee:
KSQ Therapeutics, Inc., Lexington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61P 35/00 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61P 35/00 (2018.01); C12Q 1/6886 (2013.01); C12Q 2600/156 (2013.01);
Abstract
The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein X, X, X, X, R, R, R, R, R, and Rare defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.