The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2022
Filed:
Aug. 17, 2021
Qingdao Harwars Biology Group Ltd., Qingdao, CN;
Mingyi Li, Qingdao, CN;
Gang Liu, Qingdao, CN;
Chunlin Yi, Qingdao, CN;
Fenglong Ma, Qingdao, CN;
Zongke Wang, Qingdao, CN;
Yujie Xia, Qingdao, CN;
Xiaochen Cui, Qingdao, CN;
Zhen Yang, Qingdao, CN;
Hongshang Chang, Qingdao, CN;
Bingbing Zhao, Qingdao, CN;
Jie Yang, Qingdao, CN;
QINGDAO HARWARS BIOLOGY GROUP LTD., Qingdao, CN;
Abstract
A paramyxovirus vaccine strain for novel coronavirus pneumonia and a construction method thereof are provided. The method includes performing a recombination of N and F genes of Newcastle disease virus type VII of Paramyxoviridae with P, M, H, L genes of Canine distemper virus of Paramyxoviridae to obtain a recombinant virus, inserting S1 gene of the novel coronavirus between the P and M genes of the recombinant virus to obtain a recombinant vector. The vaccine strain constructed can stably and efficiently express the novel coronavirus S1 protein, and induce the body to produce antibodies; and the recombined virus vaccine strain can stimulate the human body to produce mucosal immunity, and the prepared vaccine can be vaccinated through a nasal spray. Moreover, the vaccine strain can be tested in poultry and dogs, saving time, reducing costs, and being more conducive to actual production due to large output.