The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2022
Filed:
Aug. 04, 2017
Applicants:
Universitat Zurich, Zurich, CH;
Universitat Basel, Basel, CH;
Inventors:
Assignees:
UNIVERSITÄT BASEL, Basel, CH;
UNIVERSITÄT ZURICH, Zurich, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 45/06 (2006.01); C07K 14/74 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1774 (2013.01); A61K 38/177 (2013.01); A61K 39/0011 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 48/00 (2013.01); C07K 14/70539 (2013.01); C07K 16/00 (2013.01); C07K 16/2803 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01);
Abstract
The invention relates to a HLA-B27 Fc open conformer or a HLA-B27 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B27 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B27 Fc open conformer and immune checkpoint inhibitors.