The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2022
Filed:
Mar. 14, 2018
Applicant:
Baylor College of Medicine, Houston, TX (US);
Inventors:
Assignee:
Baylor College of Medicine, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07H 21/02 (2006.01); A61K 35/34 (2015.01); C07K 14/47 (2006.01); C12N 5/077 (2010.01); A61K 48/00 (2006.01); A01K 67/027 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/34 (2013.01); A61K 48/00 (2013.01); C07K 14/4702 (2013.01); C12N 5/0657 (2013.01); A01K 67/0278 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); A61K 38/00 (2013.01);
Abstract
The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.