The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2022
Filed:
Jun. 16, 2017
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); G01N 33/50 (2006.01); C12Q 1/6883 (2018.01); C12N 5/071 (2010.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); C12N 5/0686 (2013.01); C12N 15/1093 (2013.01); C12N 15/1138 (2013.01); G01N 33/5014 (2013.01); C12N 2310/11 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/166 (2013.01);
Abstract
The invention relates to methods for predicting the in vivo nephrotoxicity of a nucleic acid molecule, in particular a nucleic acid molecule such as a siRNA or an antisense oligonucleotide using an in vitro cell based assay measuring the levels of EGFR as toxicity biomarker, potentially in combination with other biomarkers like ATP and KIM-1.