The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2022
Filed:
May. 11, 2020
Cytokinetics, Incorporated, South San Francisco, CA (US);
Ippei Sato, Tokyo, JP;
Takashi Kamikubo, Tokyo, JP;
Masanori Miura, Tokyo, JP;
Yuji Matsushima, Tokyo, JP;
Hiroaki Tanaka, Tokyo, JP;
Yasuhiro Shiina, Tokyo, JP;
Susumu Yamaki, Tokyo, JP;
Tomoyuki Saito, Tokyo, JP;
Hiroshi Kiyohara, Tokyo, JP;
Munemichi Ohe, Tokyo, JP;
Kayoko Mihara, Tokyo, JP;
Bradley Paul Morgan, Moraga, CA (US);
Fady Malik, Burlingame, CA (US);
Scott Emile Collibee, San Carlos, CA (US);
Luke Ashcraft, San Francisco, CA (US);
Pu-Ping Lu, Foster City, CA (US);
Jeffrey Michael Warrington, San Mateo, CA (US);
Marc Garard, San Leandro, CA (US);
Cytokinetics, Incorporated, South San Francisco, CA (US);
Abstract
Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.