logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11478727 B1

PDFFull Text
Date of Patent:
Oct. 25, 2022

Filed:

Apr. 14, 2020

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution lc-ms of biomolecules and small molecules

Applicant:

Waters Technologies Corporation, Milford, MA (US);

Inventors:

Matthew A. Lauber, North Smithfield, RI (US);

Jennifer M. Nguyen, Uxbridge, MA (US);

Ximo Zhang, Framingham, MA (US);

Nilini Ranbaduge, Hopkinton, MA (US);

Robert Birdsall, Westborough, MA (US);

Henry Shion, Hopkinton, MA (US);

Melvin Blaze Muttikal Thomas, Stratford, CT (US);

Thomas Walter, Ashland, MA (US);

Assignee:

Waters Technologies Corporation, Milford, MA (US);

Attorneys:

Womble Bond Dickinson (US) LLP

Deborah M. Vernon

Primary Examiner:

Ryan B Huang

Int. Cl.
CPC ...
B01D 15/16 (2006.01); B01D 15/30 (2006.01); B01D 15/38 (2006.01); B01D 3/02 (2006.01); G01N 30/72 (2006.01); B01J 20/26 (2006.01); B01J 20/283 (2006.01); B01J 20/22 (2006.01); B01J 20/285 (2006.01); B01J 20/28 (2006.01); C07C 67/54 (2006.01);
U.S. Cl.
CPC ...
B01D 15/166 (2013.01); B01D 3/02 (2013.01); B01D 15/305 (2013.01); B01D 15/3847 (2013.01); B01J 20/22 (2013.01); B01J 20/261 (2013.01); B01J 20/283 (2013.01); B01J 20/285 (2013.01); B01J 20/28052 (2013.01); C07C 67/54 (2013.01); G01N 30/7233 (2013.01); B01J 2220/54 (2013.01);
Abstract

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Find Patent Forward Citations

Quick Actions:

Lauber, Matthew. (2022). Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution lc-ms of biomolecules and small molecules (U.S. Patent No. 11478727). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11478727

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…