The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2022

Filed:

Sep. 01, 2021
Applicants:

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Bayer Aktiengesellschaft, Leverkusen, DE;

Inventors:

Hans-Georg Lerchen, Leverkusen, DE;

Anne-Sophie Rebstock, Champagne au Mont d'Or, FR;

Beatrix Stelte-Ludwig, Wülfrath, DE;

Dennis Kirchhoff, Berlin, DE;

Lisa Dietz, Wuppertal, DE;

Christoph Mahlert, Wuppertal, DE;

Simone Greven, Dormagen, DE;

Stephan Märsch, Cologne, DE;

Sandra Berndt, Hohen Neuendorf, DE;

Anette Sommer, Berlin, DE;

Stefanie Hammer, Berlin, DE;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/68 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 47/65 (2017.08); A61K 47/6849 (2017.08); A61K 47/6855 (2017.08); A61P 35/00 (2018.01); C07K 16/2827 (2013.01); C07K 16/2863 (2013.01); C07K 16/2866 (2013.01); C07K 16/2878 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01);
Abstract

The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.


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