The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2022

Filed:

Jul. 08, 2016
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Ivan M. Borrello, Baltimore, MD (US);

Kimberly A. Noonan, Baltimore, MD (US);

Drew M. Pardoll, Brookeville, MD (US);

Valentina Hoyos Velez, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 14/47 (2006.01); A61K 35/17 (2015.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 35/17 (2013.01); C07K 14/4748 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01);
Abstract

In some embodiments, marrow-infiltrating lymphocytes ('MILs') comprising a chimeric antigen receptor ('CAR') are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.


Find Patent Forward Citations

Borrello, Ivan. (2022). Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy (U.S. Patent No. 11478548). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11478548

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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