The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2022
Filed:
Jul. 08, 2016
The Johns Hopkins University, Baltimore, MD (US);
Ivan M. Borrello, Baltimore, MD (US);
Kimberly A. Noonan, Baltimore, MD (US);
Drew M. Pardoll, Brookeville, MD (US);
Valentina Hoyos Velez, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
In some embodiments, marrow-infiltrating lymphocytes ('MILs') comprising a chimeric antigen receptor ('CAR') are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.