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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11478461 B1

PDFFull Text
Date of Patent:
Oct. 25, 2022

Filed:

Apr. 15, 2019

[1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Liangqin Guo, Monroe Township, NJ (US);

Hongjun Zhang, Boston, MA (US);

Ping Chen, Edison, NJ (US);

Dane Clausen, Rahway, NJ (US);

Xavier Fradera, Boston, MA (US);

Yongxin Han, Needham, MA (US);

Shuwen He, Fanwood, NJ (US);

Xianhai Huang, Warren, NJ (US);

Alexander Pasternak, Jamaica Plain, MA (US);

Qinglin Pu, Needham, MA (US);

Li Xiao, Cranbury, NJ (US);

Feng Ye, Scotch Plains, NJ (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Baerbel R. Brown

Catherine D. Fitch

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 45/06 (2006.01); C07C 237/22 (2006.01); C07C 255/60 (2006.01); C07D 213/75 (2006.01); C07C 271/36 (2006.01); C07C 233/78 (2006.01); C07C 271/24 (2006.01); C07C 233/79 (2006.01); C07D 213/81 (2006.01); C07D 271/06 (2006.01); C07D 239/28 (2006.01); C07D 215/48 (2006.01); C07C 275/30 (2006.01); C07C 275/28 (2006.01); C07D 239/42 (2006.01); C07D 305/06 (2006.01); C07D 261/08 (2006.01); C07D 471/04 (2006.01); C07D 261/20 (2006.01); C07D 209/34 (2006.01); C07D 277/56 (2006.01); C07D 217/02 (2006.01); C07D 231/14 (2006.01); C07D 237/28 (2006.01); C07D 241/24 (2006.01); C07D 217/26 (2006.01); A61K 31/167 (2006.01); A61K 31/27 (2006.01); A61K 31/4245 (2006.01); A61K 31/47 (2006.01); A61K 31/17 (2006.01); A61K 31/505 (2006.01); A61K 31/337 (2006.01); A61K 31/437 (2006.01); A61K 31/42 (2006.01); A61K 31/426 (2006.01); A61K 31/472 (2006.01); A61K 31/415 (2006.01); A61K 31/4965 (2006.01);
U.S. Cl.
CPC ...
A61K 31/44 (2013.01); A61K 31/167 (2013.01); A61K 31/17 (2013.01); A61K 31/27 (2013.01); A61K 31/337 (2013.01); A61K 31/415 (2013.01); A61K 31/42 (2013.01); A61K 31/426 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/47 (2013.01); A61K 31/472 (2013.01); A61K 31/4965 (2013.01); A61K 31/505 (2013.01); A61K 45/06 (2013.01); C07C 233/78 (2013.01); C07C 233/79 (2013.01); C07C 237/22 (2013.01); C07C 255/60 (2013.01); C07C 271/24 (2013.01); C07C 271/36 (2013.01); C07C 275/28 (2013.01); C07C 275/30 (2013.01); C07D 209/34 (2013.01); C07D 213/75 (2013.01); C07D 213/81 (2013.01); C07D 215/48 (2013.01); C07D 217/02 (2013.01); C07D 217/26 (2013.01); C07D 231/14 (2013.01); C07D 237/28 (2013.01); C07D 239/28 (2013.01); C07D 239/42 (2013.01); C07D 241/24 (2013.01); C07D 261/08 (2013.01); C07D 261/20 (2013.01); C07D 271/06 (2013.01); C07D 277/56 (2013.01); C07D 305/06 (2013.01); C07D 471/04 (2013.01);
Abstract

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

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