The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Jun. 28, 2021
Applicant:
Tempus Labs, Inc., Chicago, IL (US);
Inventors:
Ariane Lozac'hmeur, Chicago, IL (US);
Jason Perera, Chicago, IL (US);
Assignee:
TEMPUS LABS, INC., Chicago, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16B 20/10 (2019.01); G16B 30/10 (2019.01); G16B 40/00 (2019.01);
U.S. Cl.
CPC ...
G16B 20/10 (2019.02); G16B 30/10 (2019.02); G16B 40/00 (2019.02);
Abstract
Processes are provided for detecting loss of heterozygosity of Human Leukocyte Antigen (HLA) in a subject using analysis of next generation sequencing (NGS) data. The processes include aligning NGS data and identifying unmapped and mapped reads, updating reference data, and feeding one or more sequence reads to an HLA typing process for identifying candidate HLA alleles and feeding HLA type data to a loss of heterozygosity (LOH) modeling process for determining a LOH status for each HLA allele. A report may be generated of the LOH statuses for each of HLA allele.