The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Jun. 04, 2018
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Baris R. Mutlu, Cambridge, MA (US);

Jon F. Edd, Wakefield, MA (US);

Mehmet Toner, Charlestown, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 15/14 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1459 (2013.01); G01N 15/1404 (2013.01); G01N 15/1484 (2013.01); B01L 2200/0652 (2013.01); B01L 2400/04 (2013.01); G01N 2015/1413 (2013.01);
Abstract

This disclosure provides systems and methods to extend the capabilities of inertial and/or viscoelastic focusing in channels, such as microchannels. The new systems and methods can be integrated with existing microfluidic devices for inertial and/or viscoelastic manipulation of particles that have defied prior attempts, enabling a variety of applications in clinical diagnosis. The particles, e.g., bioparticles and cells, focus into streamlines in the same way and in the same locations as in existing inertial and viscoelastic focusing systems, but at much lower particle Reynolds numbers, much lower shear stress, over much shorter distances, and at lower driving pressures and/or flow rates.


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