The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Jul. 06, 2016
Merck Patent Gmbh, Darmstadt, DE;
Claus-Peter Niesert, Seeheim-Jugenheim, DE;
Helge B. Bode, Oberursel, DE;
Kenan Bozhueyuek, Frankfurt am Main, DE;
Florian Fleischhacker, Friedberg, DE;
JOHANN WOLFGANG GOETHE-UNIVERSITAT, Frankfurt am Main, DE;
Abstract
The present invention concerns a novel method for the modification and/or custom-made design of artificial non-ribosomal peptide synthetases (NRPSs) from naturally available NRPSs. The artificial NRPSs are of predetermined length and amino acid composition and sequence. Via fusion of well-defined NRPS units (so-called 'exchange units') in a certain manner, using a specific sequence motif in the linker areas it is possible to construct artificial and/or modified NRPS assembly lines, which have the ability of synthesizing peptides of a desired structure.