The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Aug. 24, 2021
Applicant:
Illumina Cambridge Limited, Cambridge, GB;
Inventors:
Geoffrey Paul Smith, Cambridge, GB;
David Mark Dunstan Bailey, Cambridge, GB;
Raquel Maria Sanches-Kuiper, Cambridge, GB;
Harold Swerdlow, Cambridge, GB;
David James Earnshaw, Cambridgeshire, GB;
Assignee:
ILLUMINA CAMBRIDGE LIMITED, Cambridge, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
C12N 9/1252 (2013.01); C12Q 1/6869 (2013.01); C12Y 207/07007 (2013.01);
Abstract
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3' position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.