The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Jul. 31, 2018
Applicant:

Universität Bern, Bern, CH;

Inventors:

Olivier Thierry Guenat, Bern, CH;

Marcel Felder, Bern, CH;

Andreas Stucki, Bern, CH;

Janick Daniel Stucki, Bern, CH;

Thomas Geiser, Hinterkappelen, CH;

Assignee:

Universität Bern, Bern, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); C12M 1/12 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12M 1/34 (2006.01);
U.S. Cl.
CPC ...
C12M 21/08 (2013.01); C12M 25/02 (2013.01); C12M 25/04 (2013.01); C12M 29/10 (2013.01); C12M 35/04 (2013.01); C12M 35/08 (2013.01); C12M 41/40 (2013.01);
Abstract

A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.


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