The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Feb. 10, 2020
Applicants:
California Institute of Technology, Pasadena, CA (US);
The Rockefeller University, New York, NY (US);
Inventors:
Ron Diskin, Rehovot, IL;
Pamela J. Bjorkman, Pasadena, CA (US);
Michel C. Nussenzweig, New York, NY (US);
Johannes Scheid, New York, NY (US);
Assignees:
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US);
THE ROCKEFELLER UNIVERSITY, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1063 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C12N 2740/16111 (2013.01);
Abstract
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.