The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Mar. 27, 2017
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventor:
Martin Marsala, La Jolla, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61K 48/00 (2006.01); C12N 9/88 (2006.01); A61P 25/14 (2006.01); C07C 235/42 (2006.01); C07C 233/69 (2006.01); C07C 235/34 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70571 (2013.01); A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61P 25/14 (2018.01); C07C 233/69 (2013.01); C07C 235/34 (2013.01); C07C 235/42 (2013.01); C12N 9/88 (2013.01); C12Y 401/01015 (2013.01); C12N 2710/00 (2013.01); C12N 2750/14143 (2013.01);
Abstract
The present invention provides a therapy for treating loss of GABA-mediated pre-synaptic inhibition after spinal injury. The therapeutic regimen includes spinal segment-specific upregulation of GAD65 (glutamate decarboxylase) and VGAT (vesicular GABA transporter) to modulate chronic spasticity in patients after spinal traumatic or ischemic injury.