The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Mar. 06, 2019
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Jian Jin, New York, NY (US);
Jing Liu, New York, NY (US);
Ramon E. Parsons, Manhasset, NY (US);
Jia Xu, New York, NY (US);
Xufen Yu, New York, NY (US);
Assignee:
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 401/14 (2006.01); C07D 487/04 (2006.01); G01N 33/50 (2006.01); A61P 35/00 (2006.01); A61K 31/436 (2006.01); A61K 31/496 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/436 (2013.01); A61K 31/496 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 487/04 (2013.01); G01N 33/5011 (2013.01); G01N 2333/90 (2013.01); G01N 2333/912 (2013.01);
Abstract
Disclosed herein are serine threonine kinase (AKT) degradation/disruption compounds including an AKT ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of AKT-mediated diseases.