The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Jun. 19, 2018
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Celia Schiffer, Shrewsbury, MA (US);
Akbar Ali, Westborough, MA (US);
Ashley Matthew, Worcester, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/20 (2006.01); A61P 31/14 (2006.01); A61K 31/498 (2006.01); C07K 5/083 (2006.01); C07K 5/103 (2006.01); C07K 5/107 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 241/20 (2013.01); A61K 31/498 (2013.01); A61P 31/14 (2018.01); C07K 5/0808 (2013.01); C07K 5/101 (2013.01); C07K 5/1016 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.